Evidence for an interaction between proinsulin C-peptide and GPR146
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چکیده
منابع مشابه
Proinsulin C-peptide--biological activity?
Insulin—a hormone critical for the control of blood glucose—is first synthesized as a longer prohormone. During its maturation, a peptide, C-peptide, is cleaved from the protein, but has been thought to be biologically inert. [HN2], [HN3] Defying the rule that peptide hormones act only by binding to stereospecific receptors, Ido et al. (1) report on page 563 of this issue that C-peptide not onl...
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The C-peptide links the insulin A and B chains in proinsulin, providing thereby a means to promote their efficient folding and assembly in the endoplasmic reticulum during insulin biosynthesis. It then facilitates the intracellular transport, sorting, and proteolytic processing of proinsulin into biologically active insulin in the maturing secretory granules of the beta cells. These manifold fu...
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In recent years the physiological role of the proinsulin C-peptide has received increasing attention, focusing on the potential therapeutic value of C-peptide replacement in preventing and ameliorating type 1 diabetic complications. In order to consolidate these new data and to identify the immediate directions of C-peptide research and its clinical usefulness, an International Symposium was he...
متن کاملIsolation and characterization of proinsulin C-peptide from bovine pancreas.
Although the enzymes that catalyze the transformation of proinsulin to insulin have not yet been identified, studies of intermediate forms of proinsulin isolated from bovine pancreas indicate the existence of a mechanism in which the interchain connecting peptide is cleaved with elimination of a pair of basic residues from each end to yield insulin and the intact remainder of the connecting pep...
متن کاملMetabolism of proinsulin, insulin, and C-peptide in the rat.
The renal extraction and excretion of bovine proinsulin, insulin, and C-peptide and the contribution of the kidney to their total metabolic clearance rate (MCR) were studied in the rat. Metabolic clearance rates were measured by the constant infusion technique and plasma and urine concentrations of each polypeptide were determined by radioimmunoassay. The MCR of insulin (16.4+/-0.4 ml/min) was ...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2013
ISSN: 0022-0795,1479-6805
DOI: 10.1530/joe-13-0203